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1

A Convenient Synthesis of 1-Aryl-4-piperidones

Taylor, Edward C., Skotnicki, Jerauld S.

Journal:

Year:

1981

File:

PDF, 145 KB

1981

2

Reactions of sodium borohydride in acidic media. I. Reduction of indoles and alkylation of aromatic amines with carboxylic acids

Gribble, Gordon W., Lord, Pierre D., Skotnicki, Jerauld, Dietz, Stephen E., Eaton, Jefferson T., Johnson, Jerry

Journal:

Journal of the American Chemical Society

Year:

1974

Language:

english

File:

PDF, 390 KB

english, 1974

3

The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position

Jeremy I Levin, Mila T Du, John F DiJoseph, Loran M Killar, Amy Sung, Thomas Walter, Michele A Sharr, Catherine E Roth, Franklin J Moy, Robert Powers, Guixian Jin, Rebecca Cowling, Jerauld S Skotnicki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

4

ChemInform Abstract: REACTIONS OF SODIUM BOROHYDRIDE IN ACIDIC MEDIA PART 1, REDUCTION OF INDOLES AND ALKYLATION OF AROMATIC AMINES WITH CARBOXYLIC ACIDS

GRIBBLE, GORDON W., LORD, PIERRE D., SKOTNICKI, JERAULD, DIETZ, STEPHEN E., EATON, JEFFERSON T., JOHNSON, JERRY L.

Journal:

Chemischer Informationsdienst

Year:

1975

File:

PDF, 211 KB

1975

5

Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Aranapakam, Venkatesan, Davis, Jamie M., Grosu, George T., Baker,, Ellingboe, John, Zask, Arie, Levin, Jeremy I., Sandanayaka, Vincent P., Du, Mila, Skotnicki, Jerauld S.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 495 KB

english, 2003

6

Synthesis and Structure−Activity Relationship of α-Sulfonylhydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis

Aranapakam, Venkatesan, Grosu, George T., Davis, Jamie M., Hu, Baihua, Ellingboe, John, Baker, Jannie L., Skotnicki, Jerauld S., Zask, Arie, DiJoseph, John F., Sung, Amy, Sharr, Michele A., Killar, Lo

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

7

A convenient synthesis of 1-benzhydryl-N-arylsulfonyl-3-oxo-1,2-diazetidine-2-carboxamides.

SKOTNICKI, JERAULD S.

Journal:

The Journal of Antibiotics

Year:

1986

Language:

english

File:

PDF, 1.02 MB

english, 1986

8

Synthesis of secorapamycin esters and amides

Jerauld S. Skotnicki, Robert M. Kearney, Andri L. Smith

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 258 KB

english, 1994

9

The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinases

Jeremy I. Levin, John F. DiJoseph, Loran M. Killar, Michele A. Sharr, Jerauld S. Skotnicki, Dinesh V. Patel, Xiao-Yi Xiao, Lihong Shi, Marc Navre, David A. Campbell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 346 KB

english, 1998

10

Ring expanded rapamycin derivatives

Jerauld S. Skotnicki, Robert M. Kearney

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 167 KB

english, 1994

11

Synthesis of rapamycin glycoconjugates via a CuAAC-based approach

Moni, Lisa, Marra, Alberto, Skotnicki, Jerauld S., Koehn, Frank E., Abou-Gharbia, Magid, Dondoni, Alessandro

Journal:

Tetrahedron Letters

Year:

2013

Language:

english

File:

PDF, 748 KB

english, 2013

12

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis

Yonghan Hu, Jason S. Xiang, Martin J. DiGrandi, Xuemei Du, Manus Ipek, Leif M. Laakso, Jianchang Li, Wei Li, Thomas S. Rush, Jean Schmid, Jerauld S. Skotnicki, Steve Tam, Jennifer R. Thomason, Qin Wan

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 336 KB

english, 2005

13

Prostaglandins and congeners. 22. Synthesis of 11-substituted derivatives of 11-deoxyprostaglandins E1 and E2. Potential bronchodilators

Floyd, M. Brawner, Schaub, Robert E., Siuta, Gerald J., Skotnicki, Jerauld S., Grudzinskas, Charles V., Weiss, Martin J., Dessy, Franz, VanHumbeeck, L.

Journal:

Journal of Medicinal Chemistry

Year:

1980

Language:

english

File:

PDF, 1.23 MB

english, 1980

14

Synthesis of 1-(p-carbomethoxyphenyl)-3-pyrrolidinone by a Diels-Alder route

Taylor, Edward C., McDaniel, Keith, Skotnicki, Jerauld S.

Journal:

Journal of Organic Chemistry

Year:

1984

Language:

english

File:

PDF, 305 KB

english, 1984

15

Synthesis and Structure−Activity Relationships of 4-alkynyloxy Phenyl Sulfanyl, Sulfinyl, and Sulfonyl Alkyl Hydroxamates as Tumor Necrosis Factor-α Converting Enzyme and Matrix Metalloproteinase Inhibitors

Venkatesan, Aranapakam M., Davis, Jamie M., Grosu, George T., Baker, Jannie, Zask, Arie, Levin, Jeremy I., Ellingboe, John, Skotnicki, Jerauld S., DiJoseph, John F., Sung, Amy, Jin, Guixian, Xu, Weixi

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 606 KB

english, 2004

16

Prostaglandins and congeners. 14. Synthesis and bronchodilator activity of dl-16,16-trimethyleneprostaglandins

Skotnicki, Jerauld S., Schaub, Robert E., Weiss, Martin J., Dessy, F.

Journal:

Journal of Medicinal Chemistry

Year:

1977

Language:

english

File:

PDF, 847 KB

english, 1977

17

Benzodiazepine inhibitors of the MMPs and TACE

Frances C Nelson, Efren Delos Santos, Jeremy I Levin, James M Chen, Jerauld S Skotnicki, John F DiJoseph, Michele A Sharr, Amy Sung, Loran M Killar, Rebecca Cowling, Guixian Jin, Catherine E Roth, J.D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

18

Synthesis and antibacterial activity of novel aminothiazolyl .BETA.-lactam derivatives.

SKOTNICKI, JERAULD S., STEINBAUGH, BRUCE A.

Journal:

The Journal of Antibiotics

Year:

1986

Language:

english

File:

PDF, 3.86 MB

english, 1986

19

3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding

Wei Li, Yonghan Hu, Jianchang Li, Jennifer R. Thomason, Dianne DeVincentis, Xuemei Du, Junjun Wu, Rajeev Hotchandani, Thomas S. Rush III, Jerauld S. Skotnicki, Steve Tam, Priya S. Chockalingam, Elisab

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 537 KB

english, 2009

20

Design and Synthetic Considerations of Matrix Metalloproteinase Inhibitors

JERAULD S. SKOTNICKI, ARIE ZASK, FRANCES C. NELSON, J. DONALD ALBRIGHT, JEREMY I. LEVIN

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 502 KB

english, 1999

21

Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors

Arie Zask, Joshua Kaplan, XueMei Du, Gloria MacEwan, Vincent Sandanayaka, Nancy Eudy, Jeremy Levin, Guixian Jin, Jun Xu, Terri Cummons, Dauphine Barone, Semiramis Ayral-Kaloustian, Jerauld Skotnicki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 128 KB

english, 2005

22

The synthesis and biological activity of a novel series of diazepine MMP inhibitors

Jeremy I. Levin, John F. DiJoseph, Loran M. Killar, Amy Sung, Thomas Walter, Michele A. Sharr, Catherine E. Roth, Jerauld S. Skotnicki, J.Donald Albright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 276 KB

english, 1998

23

Improved Synthesis of 1,5-Bis(Dimethylamino)-1,4-Pentadien-3-One

Taylor, Edward C., Skotnicki, Jerauld S.

Journal:

Synthetic Communications

Year:

1983

Language:

english

File:

PDF, 84 KB

english, 1983

24

Heterocyclization with cyano and sulfonyl epoxides. Preparation of quinoxalines and tetrahydroquinoxalines

Taylor, Edward C., Maryanoff, Cynthia A., Skotnicki, Jerauld S.

Journal:

Journal of Organic Chemistry

Year:

1980

Language:

english

File:

PDF, 583 KB

english, 1980

25

Synthesis and biological evaluation of a 4-fluoromethyl monobactam analog.

SKOTNICKI, JERAULD S., COMMONS, THOMAS J., REES, RICHARD W., SPETH, JOHN L.

Journal:

The Journal of Antibiotics

Year:

1983

Language:

english

File:

PDF, 1.82 MB

english, 1983

26

Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-deoxy-3-thiaprostaglandins

Skotnicki, Jerauld S., Schaub, Robert E., Weiss, Martin J., Dessy, Franz

Journal:

Journal of Medicinal Chemistry

Year:

1977

Language:

english

File:

PDF, 549 KB

english, 1977

27

2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis

Zhong Li, Gerardo D. Francisco, William Hu, Pornpen Labthavikul, Peter J. Petersen, Anatoly Severin, Guy Singh, Youjun Yang, Beth A. Rasmussen, Yang-I Lin, Jerauld S. Skotnicki, Tarek S. Mansour

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 144 KB

english, 2003

28

Synthesis of D,L-7,10-ethano-5-deazaaminopterin and L-7,10-ethano-5-deazafolic acid

Taylor, Edward C., Skotnicki, Jerauld S., Fletcher, Stephen R.

Journal:

Journal of Organic Chemistry

Year:

1985

Language:

english

File:

PDF, 815 KB

english, 1985

29

[Annual Reports in Medicinal Chemistry] Volume 38 || Chapter 16. TNF-α converting enzyme (TACE) as a therapeutic target

Skotnicki, Jerauld S.

Year:

2003

Language:

english

File:

PDF, 699 KB

english, 2003

30

Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins

Skotnicki, Jerauld S., Schaub, Robert E., Bernady, Karel F., Siuta, Gerald J., Poletto, John F., Weiss, Martin J., Dessy, Franz

Journal:

Journal of Medicinal Chemistry

Year:

1977

Language:

english

File:

PDF, 938 KB

english, 1977

31

Synthesis and antibacterial activity of C-3' isothiazolyl and related cephalosporins.

SKOTNICKI, JERAULD S., STRIKE, DONALD P.

Journal:

The Journal of Antibiotics

Year:

1986

Language:

english

File:

PDF, 1.93 MB

english, 1986

32

Synthesis and SAR of highly selective MMP-13 inhibitors

Jianchang Li, Thomas S. Rush III, Wei Li, Dianne DeVincentis, Xuemei Du, Yonghan Hu, Jennifer R. Thomason, Jason S. Xiang, Jerauld S. Skotnicki, Steve Tam, Kristina M. Cunningham, Priya S. Chockalinga

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

33

Base catalyzed degradations of rapamycin

Robert J. Steffan, Robert M. Kearney, David C. Hu, Amedeo A. Failli, Jerauld S. Skotnicki, Robert A. Schiksnis, James F. Mattes, Kelvin W. Chan, Craig E. Caufield

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 267 KB

english, 1993

34

NMR Solution Structure of the Catalytic Fragment of Human Fibroblast Collagenase Complexed with a Sulfonamide Derivative of a Hydroxamic Acid Compound ‡

Moy, Franklin J., Chanda, Pranab K., Chen, James M., Cosmi, Scott, Edris, Wade, Skotnicki, Jerauld S., Wilhelm, Jim, Powers, Robert

Journal:

Year:

1999

Language:

english

File:

PDF, 166 KB

english, 1999

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